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Causes Pathogenesis Symptoms of insulin allergy Complications Diagnosis Treatment of insulin allergy Prognosis and prevention Prices for treatment.

Systemic reactions are rare, characterized by skin manifestations (urticaria, Quincke's edema), anaphylaxis. Allergy to insulin is observed in 5-30% of flagyl with diabetes mellitus, decreasing with the transition to modern purified preparations (DNA-recombinant human insulin) and strict adherence to the technology of drug administration.

In the treatment of diabetes, various preparations of insulin (bovine, porcine, human) are used, differing in the degree of purification and the content of protein or non-protein impurities.

Mostly, allergic reactions occur to insulin itself, much less often to protamine, zinc and other substances contained in Metronidazole drug.

The smallest number of allergic reactions is observed when using various types of human insulin, the largest - with the introduction of animal insulins.

The most immunogenic is bovine insulin, the difference from human insulin is most pronounced (two other amino acid residues of the A-chain and one of the B-chain).
Less allergenicity - in porcine insulin (the difference is only Flagyl in one amino acid residue of the B-chain).

The U.S. Bureau of Labor and Statistics states:

Number withThe incidence of insulin allergy has significantly decreased after the introduction of highly purified insulins (proinsulin content less than 10 μg/g) into clinical practice. The development of local reactions may be associated with improper administration of flagyl drugs (intradermally, with a thick needle and the associated excessive trauma to the skin, the wrong choice of injection site, a heavily chilled drug, etc.).

Symptoms of an allergy to insulin.
Hypersensitivity to administered Flagyl drugs is formed with the participation of antibodies of various classes. Early local allergic reactions and anaphylaxis are usually caused by immunoglobulins E. The occurrence of local reactions 5-8 hours after the administration of insulin preparations and the development of insulin resistance are associated with IgG. Allergy to insulin, which develops 12-24 hours after the administration of the drug, usually indicates a delayed-type allergic reaction (to insulin itself or to zinc present in the preparation).

Flagyl to insulin is more often manifested by the development of mild local hypersensitivity reactions, which can occur 0.5-1 hour after administration of the drug and quickly disappear (early reactions), or 4-8 hours (sometimes 12-24 hours) after injection - delayed, late reactions, the clinical manifestations of which can persist for several days.

The main symptoms of a local allergic reaction are redness, swelling and itching at the injection site.

Itching can be local, moderate, sometimes it becomes unbearable and can spread to neighboring areas of the skin.